COVID-19

Novavax COVID-19 vaccine (NVX-CoV2373)

COVID-19 Vaccine Details
Therapeutic area
Infectious disease
Status
Technology
Respiratory diseases
COVID-19
 
Authorized1
Matrix-M™ adjuvant
Therapeutic area
Respiratory diseases
Infectious disease
COVID-19
Status
 
Authorized1
Technology
Matrix-M™ adjuvant

About the candidate

NVX-CoV2373 is a protein-based vaccine targeting SARS-CoV-2, the virus that causes COVID-19. Recombinant technology is used to create vaccine nanoparticles, which are then mixed with Matrix-M™ adjuvant to create the ready-to-use NVX-CoV2373 vaccine1. NVX-CoV2373 in the United States has received Emergency Use Authorization. 

NVX-CoV2373 vaccine design
1
SARS-CoV-2 spike protein gene inserted into insect virus

The full-length, stabilized spike gene is engineered into baculovirus.

Baculovirus.Modified spike protein gene. Viral genome. SARS-CoV-2.
2
Sf9 cells infected

Recombinant baculovirus infects moth cells in the S. frugiperda (Sf9) expression system.

Sf9 cell. Baculovirus.
3
Spike gene enters Sf9 cell nucleus

Spike DNA is transcribed.

Spike protein gene. Nucleus. mRNA.
4
Sf9 cells produce spike proteins

Spike proteins are expressed in their native trimer conformation.

Spike protein gene. Nucleus. mRNA.
5
Nanoparticle formation

Spike protein trimers are harvested. Vaccine nanoparticles assemble as spike protein trimers arranged around a Polysorbate 80 (PS80) core.

PS80 core
6
Final vaccine

Vaccine nanoparticles are mixed with Matrix-MTM adjuvant to create ready-to-use NVX-CoV2373 vaccine.

Matrix-M adjuvant.

Infographic displaying the NVX-CoV2373 vaccine design

Why it matters

COVID-19 continues to evolve around the world and is responsible for millions of deaths.2 Our NVX-CoV2373 vaccine candidate has been shown to produce robust, functional immune responses in diverse clinical trial populations.

Vaccines produced using Novavax' technology are stable at standard refrigeration temperatures, enabling NVX-CoV2373 to reach people around the world.

Authorized in select geographies under trade names Novavax COVID-19 Vaccine, Adjuvanted; Covovax™; and Nuvaxovid™, authorized in the U.S. under trade name, Novavax COVID-19 Vaccine, Adjuvanted (2023-2024 Formula); and authorized in the EU under the trade name Nuvaxovid XBB.1.5. Strain change trials for the COVID-19 vaccines ongoing. Authorization information can be found by country at https://novavaxcovidvaccine.com.

  1. Bangaru et al. Science. Available at: https://www.science. org/doi/10.1126/science.abe1502 [Accessed 25 Jan 2023]
  2. World Health Organization COVID-19 Dashboard. https://covid19.who.int [Accessed 24 Jan 2023].