Headline
Resources
Headline
Resources
Clinical Trial Protocols
Publications
| Title | Topic | Year | Link | Document | Notes |
|---|---|---|---|---|---|
| Current Protocol for Phase 3 Clinical Trial of NVX-CoV2373 in the U.S. and Mexico | COVID-19 | 2020 | Document
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| Current Protocol for Phase 3 Clinical Trial of NVX-CoV2373 in the U.K. | COVID-19 | 2020 | Document
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Updated January 6, 2021 |
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| Current Protocol for Phase 2b Clinical Trial of NVX-CoV2373 in South Africa | COVID-19 | 2020 | Document
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Publications
Publications
| Title | Topic | Year | Link | Document | Notes |
|---|---|---|---|---|---|
| SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice | COVID-19 | 2021 | https://www.nature.com/articles/s41467-020-20653-8 | Nature Communications, Tian J.H., et. al. |
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| Structural Characterization and Modeling of a Respiratory Syncytial Virus Fusion Glycoprotein Nanoparticle Vaccine in Solution | Respiratory Syncytial Virus | 2020 | https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.0c00986 | Neutron and X-ray scanning reveal structure of a candidate vaccine’s nanoparticles in a more realistic environment. |
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| Phase 1–2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine | COVID-19 | 2020 | https://www.nejm.org/doi/full/10.1056/NEJMoa2026920?query=featured_coronavirus | New England Journal of Medicine, Keech, Cheryl, et al |
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| Induction of Cross-reactive Hemagglutination Inhibiting Antibody and Polyfunctional CD4+ T-cell Responses by a Recombinant Matrix-M-Adjuvanted Hemagglutinin Nanoparticle Influenza Vaccine | Seasonal Influenza | 2020 | https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa1673/5955953 | Clinical Infectious Diseases, Shinde, Vivek, et al |
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| Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate | COVID-19 | 2020 | https://science.sciencemag.org/content/sci/early/2020/10/19/science.abe1502.full.pdf | ||
| Severe Morbidity and Short- and Mid- to Long-term Mortality in Older Adults Hospitalized with Respiratory Syncytial Virus Infection | Respiratory Syncytial Virus | 2020 | https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiaa361/5863549?guestAccessKey=375780c1-c599-4cf9-bc52-1377448b703b | Journal of Infectious Diseases, Shinde, Vivek, et al |
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| Flexible RSV Prefusogenic Fusion Glycoprotein Exposes Multiple Neutralizing Epitopes that May Collectively Contribute to Protective Immunity | Respiratory Syncytial Virus | 2020 | Document
FlexibleRSVPrefusogenicFusionGlycoprotein.pdf
(904.53 KB)
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Vaccine, Patel, Nina, et al |
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| Hemagglutinin from multiple divergent influenza A and B viruses bind to a distinct branched, sialylated poly-LacNAc glycan by surface plasmon resonance | Seasonal Influenza | 2020 | Document
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Vaccine, Bruce-Staskal, Pamela J., et al |
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| Comparison of the Safety and Immunogenicity of a Novel Matrix-M-adjuvanted Nanoparticle Influenza Vaccine with a Quadrivalent Seasonal Influenza Vaccine in Older Adults: A Randomized Controlled Trial | Seasonal Influenza | 2020 | https://medrxiv.org/cgi/content/short/2020.08.07.20170514v1 | Disclaimer: Pre-print only and not yet published in peer-reviewed article |
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| First-in-Human Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine | COVID-19 | 2020 | Disclaimer: Pre-print only and not yet published in peer-reviewed article |
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| Respiratory Syncytial Virus Vaccination during Pregnancy and Effects in Infants | Respiratory Syncytial Virus | 2020 | Document
NEJMoa1908380.pdf
(593.47 KB)
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New England Journal of Medicine, Madhi S.A., et al |
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| SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 elicits immunogenicity in baboons and protection in mice | COVID-19 | 2020 | Document
SARS-CoV2_rev75-gs_pap_le-29June2020.pdf
(1.14 MB)
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Disclaimer: Pre-print only and not yet published in peer-reviewed article |
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| Prediction of serious RSV‐related outcomes in older adults with outpatient RSV respiratory illness during 12 consecutive seasons | Respiratory Syncytial Virus | 2020 | https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12751 | Influenza and Other Respiratory Viruses | Kieke, BA, et al. |
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| Influenza Hemagglutinin Nanoparticle Vaccine Elicits Broadly Neutralizing Antibodies against Structurally Distinct Domains of H3N2 HA | Seasonal Influenza | 2020 | https://pubmed.ncbi.nlm.nih.gov/32098409/ | Vaccine, Portnoff, Alyse, et al |
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| Why Making a Diagnosis of Respiratory Syncytial Virus Should Matter to Clinicians | Respiratory Syncytial Virus | 2018 | Document
ciy880.pdf
(375.6 KB)
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Angela R. Branche, MD |
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| Improved Titers against Influenza Drift Variants with a Nanoparticle Vaccine | Seasonal Influenza | 2018 | https://www.nejm.org/doi/full/10.1056/NEJMc1803554 | New England Journal of Medicine, Shinde, Vivek, et al |
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| Severe Morbidity and Mortality Associated with Respiratory Syncytial Virus Versus Influenza Infection in Hospitalized Older Adults | Respiratory Syncytial Virus | 2018 | Document
ciy991.pdf
(802.04 KB)
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Bradley Ackerson, Hung Fu Tseng, Lina S. Sy, Zendi Solano, Jeff Slezak, Yi Luo, Christine A. Fischetti, Vivek Shinde |
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| Safety and immunogenicity of heterologous prime-boost immunization with viral-vectored malaria vaccines adjuvanted with Matrix-M™ | Matrix-M™ Adjuvant | 2017 | https://www.sciencedirect.com/science/article/pii/S0264410X17312483?via%3Dihub=#! | Vaccine, LövgrenBengtsson, Karin, et al |
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| Immunogenicity and safety of a respiratory syncytial virus fusion protein (RSV F) nanoparticle vaccine in older adults | Respiratory Syncytial Virus | 2017 | https://www.ncbi.nlm.nih.gov/pubmed/28413427 | Immun Ageing, Fries L., et al |
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| The epidemiology of medically attended respiratory syncytial virus in older adults in the United States: A systematic review | Respiratory Syncytial Virus | 2017 | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0182321 | PLOS ONE, Shinde, Vivek, et al |
Posters
Publications
| Title | Topic | Year | Link | Document | Notes |
|---|---|---|---|---|---|
| Respiratory Syncytial Virus (RSV) Pre-fusogenic F Nanoparticle Vaccine Compared to Pre-fusion F and Post-fusion F Proteins | Respiratory Syncytial Virus | 2018 | Document
Smith_RSV_2018_Poster_Final.pdf
(440.57 KB)
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11th International Respiratory Syncytial Virus Symposium |
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| Antigenic Characterization of RSV Pre-fusogenic F Nanoparticle Vaccine, Pre-F, and Post-F Proteins against a Broad Range of Neutralizing Monoclonal Antibodies and Epitope Responses in Cotton Rats | Respiratory Syncytial Virus | 2018 | Document
Nita_RSV_2018_Poster_Final.pdf
(332.05 KB)
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11th International Respiratory Syncytial Virus Symposium |
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| Binding Kinetics of RSV Pre-fusogenic F Nanoparticle Vaccine to Palivizumab and Serum Polyclonal Antibody | Respiratory Syncytial Virus | 2018 | Document
HL_RSV_2018_Poster_Final.pdf
(296.94 KB)
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11th International Respiratory Syncytial Virus Symposium |
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| Feasibility Evaluation of Blow Fill Seal Process and Compatibility with Aluminum Phosphate Adjuvanted Recombinant RSV F Nanoparticle Vaccine | Respiratory Syncytial Virus | 2018 | Document
YHLin_RSV_2018_Poster_FINAL.pdf
(619.27 KB)
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11th International Respiratory Syncytial Virus Symposium |
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| In-depth Analytical Characterization and Structural Modeling of Novavax RSV F Nanoparticle Vaccine | Respiratory Syncytial Virus | 2018 | Document
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11th International Respiratory Syncytial Virus Symposium |
Presentations
Publications
| Title | Topic | Year | Link | Document | Notes |
|---|---|---|---|---|---|
| NVX-CoV2373 Vaccine Candidate | COVID-19 | 2020 | Document
NovavaxPresentationforACIP.pdf
(1.14 MB)
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Meeting Of The Advisory Committee On Immunization Practices (ACIP) |
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| Recombinant nanoparticle COVID-19 vaccine: Platform technology for Emerging Infectious Diseases (EID) | COVID-19 | 2020 | Document
COVID19WVC20Oct20.pdf
(1.9 MB)
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2020 World Vaccine Congress Europe |
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| New Phase 2 NanoFlu data (features new cell-mediated immunity data) | Seasonal Influenza | 2020 | Document
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World Vaccine Congress Washington 2020 |
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| Recombinant nanoparticle COVID-19 vaccine: Platform technology for EID (Emerging Infectious Diseases) | COVID-19 | 2020 | Document
COVID-1.pdf
(1.44 MB)
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World Vaccine Congress Washington 2020 |
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| Phase 3 and beyond: Maternal RSV & older adult influence vaccine program | Respiratory Syncytial Virus | 2020 | Document
2020.10.01RSV-WVCWashington.pdf
(1.77 MB)
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World Vaccine Congress Washington 2020 |
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| NVX-CoV2373 COVID-19 Vaccine Candidate Phase 1/2, Part 1, Clinical Trial Results | COVID-19 | 2020 | Document
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| Progress with the Full Length Recombinant Spike Protein Nanoparticle Vaccine | COVID-19 | 2020 | Document
20200721-ISV-Presentation.pdf
(1.23 MB)
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2nd ISV COVID-19 Vaccines Virtual Congress |
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| Learnings from a Phase 3 RSV Clinical Trial | Respiratory Syncytial Virus | 2020 | Document
20200623-NYASPresentation.pdf
(1.85 MB)
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New York Academy of Sciences: Innovations in Maternal, Neonatal, and Early Infancy Vaccines |
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| NVX-CoV2373 Vaccine for COVID-19 | COVID-19 | 2020 | Document
2020-05-13WVCWebinarCOVID19v3.pdf
(1.82 MB)
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World Vaccine Congress Webinar |
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| NanoFlu Phase 3 Topline Data | Seasonal Influenza | 2020 | Document
toplineFluPhase3InvestorSlides-20200323.pdf
(729.97 KB)
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| Induction of broadly cross-reactive immune responses against A(H3N2) viruses: results of a phase 2 trial of a novel recombinant hemagglutinin saponin-adjuvanted nanoparticle influenza vaccine (“NanoFlu”) | Seasonal Influenza | 2019 | Document
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OPTIONS X for the Control of Influenza Conference |
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| Towards an Improved Wild-type Sequence Based Hemagglutination Inhibition Assay (HAI) for the Evaluation of Influenza Vaccines: Challenges and New Developments | Seasonal Influenza | 2019 | Document
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OPTIONS X for the Control of Influenza Conference |
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| Safety of Third Trimester Immunization with a Respiratory Syncytial Virus (RSV) F Protein Vaccine and Protection of Infants over the First 180 Days of Life Against All-Cause Lower Respiratory Tract Infection | Respiratory Syncytial Virus | 2019 | Document
20190808-IDSOG-Presentation.pdf
(406.22 KB)
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Infectious Diseases Society for Obstetrics and Gynecology |
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| Phase 3 Prepare Study: Efficacy and Safety of an RSV Vaccine Administered to Pregnant Women for the Prevention of RSV Lower Respiratory Tract Infection in Infants | Respiratory Syncytial Virus | 2019 | Document
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European Society for Pediatric Infectious Diseases |
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| Phase 3 and beyond: The RSV F nanoparticle vaccine for infants via maternal immunization | Respiratory Syncytial Virus | 2019 | Document
2019.04.16-World_Vaccine_Congress.pdf
(1.65 MB)
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World Vaccine Congress |
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| Data from Completed Phase 1/2 Trial of a Novel Recombinant Saponin-Adjuvanted tNIV | Seasonal Influenza | 2018 | Document
NOVAVAX_UIV_FLU_FINAL.pdf
(1.8 MB)
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Universal Influenza Vaccines (UIV) |
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| RSV F Nanoparticle Vaccine: IVM | Respiratory Syncytial Virus | 2018 | Document
NOVAVAX-WVC_RSV_2018APR3-FINAL.pdf
(1.48 MB)
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World Vaccine Congress |
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| Nanoparticle Influenza Vaccine: Older Adults | Seasonal Influenza | 2018 | Document
NOVAVAX_WVC_FLU_2018APR3_FINAL2.pdf
(1.79 MB)
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World Vaccine Congress |
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| Magnitude and Durability of Anti-F IgG and Palivizumab-Competitive Antibody (PCA) Responses One Year Following Immunization with RSV F NanoparticleV | Respiratory Syncytial Virus | 2018 | 11th International Respiratory Syncytial Virus Symposium |
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| Progress Toward a Vaccine for Maternal Immunization to Prevent Respiratory Syncytial Virus Lower Respiratory Tract Illness (RSV LRTI) in Infants | Respiratory Syncytial Virus | 2018 | 11th International Respiratory Syncytial Virus Symposium |