THE POWER AND SPEED OF GENETIC ENGINEERING

Novavax addresses urgent global public health needs with innovative technology

Recombinant Nanoparticle Vaccine Technology

Our recombinant nanoparticle vaccine technology combines the power and speed of genetic engineering to efficiently produce a new class of highly immunogenic particles that target a variety of viral pathogens. Our recombinant vaccine engineering takes a new approach to provide robust and functional immunity, which may be more efficacious than naturally occurring immunity or traditional vaccines. Using innovative proprietary recombinant nanoparticle vaccine technology, we produce vaccine candidates to efficiently and effectively respond to both known and emerging disease threats.

Nanoparticle

How we create our nanoparticles

  • DNA
    Select genetic sequences to encode vaccine antigens
  • Bacteria
    Genes are cloned into baculovirus (BV)
  • Cells
    BV infects Sf9 insect cells
  • Antigens
    Antigens are expressed and purified as multimeric nanoparticles
  • Immunogenic particle
    Immunogenic particle with antigens in native configuration are created
  • RECOMBINANT NANOPARTICLE ADVANTAGES
    Ability to tailor our vaccines to key components of pathogens to enhance functional immunity and lead to better protection against infection and disease.
  • RECOMBINANT NANOPARTICLE ADVANTAGES
    Promote superior immunogenicity and better functional immunity via our Sf9/BV insect cell platform to efficiently express large antigens and particles.
  • RECOMBINANT NANOPARTICLE ADVANTAGES
    Ability to manufacture and produce proteins that are properly folded and modified, which can be critical for functional, protective immunity.
  • RECOMBINANT NANOPARTICLE ADVANTAGES
    Ability to leverage our proprietary vaccine technology, which produces highly immunogenic vaccines in a scalable, efficient recombinant vaccine production system.

Novavax’ recombinant protein nanoparticle vaccine technology

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Matrix-M™ adjuvant technology stimulates strong responses

Novavax' saponin-based Matrix-M improves immune responses and enables vaccine dose-sparing.

Matrix-M adjuvant is a valuable component of vaccine development, providing multiple immune system enhancements, a well-understood mechanism of action, and robust clinical experience where it was shown to be well tolerated in human studies to date.

Matrix M

Matrix-M™ adjuvant

  • antigen-presenting cell (APC)
    Induces the influx of antigen-presenting cells (APC), which enhance activated T cell, B cell, and APC populations.
  • Increased neutralizing antibodies and induced long-lasting memory B cells
    Increases neutralizing antibodies and induces long-lasting memory B cells, which enhance B-cell immunity and recruit and increase the frequency of CD4+ and CD8+ T cells that enhance T-cell immunity.
  • Matrix M
    Matrix-M provides strong and long-lasting immune responses, which can enable dose-sparing.
  • Matrix-M is composed of 40 nanometer particles based on saponin extracted from the Quillaja saponaria Molina bark together with cholesterol and phospholipid.
  • Matrix-M enhanced biologic functions to generate potent, robust, and long-lasting protective immune responses.
  • Matrix-M can lower the dose of antigen required to achieve the desired immune response, which results in fewer vaccine doses needed and increased supply and manufacturing capacity.